1.
Mode of action of Pathway
The process of
cell signaling through hydrogen peroxide is a very sensitive approach that
initiates itself with determined pathways. This is a mode noted through redox
signaling, where there are many receptors acting by the means of NADPH oxidase
(NOX) in order to create reactive oxygen species, like those of superoxide
radical (O2−•)
added by hydrogen peroxide (H2O2). This activity is
subject to regulate determined action of signaling proteins like those of tyrosine
phosphatases, led by transcription modes and ion channels. It is the O2
−• participation in nitrosylation
reaction that leads to determined Pathway 7.
2. Chronology of
Cell Signaling Research